Highly pathogenic avian influenza (HPAI) mainly due to H5N1 clade 2.3.4.4b, D1.1 genotype, is responsible for ongoing losses in many nations attesting to the panornitic status of the disease.

During January 2025 Japan reported 14 outbreaks to the World Organization of Animal Health of which one involved a quail farm but with the remainder all table egg flocks. A total of 3.8 million hens have been depopulated through January 27^th representing 2.2 percent of the population of approximately 170 million.

South Korea has recorded 29 outbreaks of HPAI among commercial poultry including ducks and laying hens since October 2024. The incidence conforms to the migratory patterns of marine birds and waterfowl.

Canada confirmed 51 cases of HPAI in 2024 requiring depopulation of 14.5 million commercial turkeys, broilers or laying hens. Losses were recorded in British Columbia (8.7 million), Alberta (2.0 million), Quebec (1.4 million) and Ontario (1.1 million). Month to date losses comprise British Columbia with four cases and Ontario, two cases.