The United Kingdom Health Security Agency in collaboration with the World College of General Practitioners is investigating the epidemiology of variant influenza viruses isolated from human patients. A recent clinical case yielded influenza A(H1N2)v with serotype H1N2. This influenza virus is circulating in hogs based on sequencing of the viral genome. Symptoms in the patient were mild followed by complete recovery. Investigations are in progress to determine whether contacts of the patient were infected. Epidemiologic studies are in progress to determine how the individual was infected and to evaluate possible extension from the index patient.