The USDA-APHIS has confirmed a diagnosis of highly-pathogenic avian influenza in a large egg-production complex in Newcastle County, DE. located approximately 10 miles south of the point of intersection of the states of DE, PA and MD. The flock is undergoing depletion. The enterprise has a second complex in Monmouth County, NJ. that should be subjected to surveillance in addition to the DE control zone. The outbreak is not unexpected given the prevalence of waterfowl shedding H5N1 HPAI virus along the Atlantic Flyway. What is now important is a prompt preliminary opinion for the guidance of our industry on the possible deficiencies in either structural or operational biosecurity that allowed introduction of the infection onto the complex.