An influenza A strain H1N2 variant virus was detected in two individuals with a history of contact with hogs during mid-December 2020.  There is concern over the emergence of variants that circulate in commercial hogs that are susceptible to both mammalian and avian strains of avian influenza. Antigenic shift may occur in the viral genome when the infection circulates in large populations of livestock in close concentration and with deficient biosecurity. It is possible that mutations could result in a strain that is infectious among humans.  Authorities in Brazil are conducting surveillance with application of sequencing to detect the emergence of strains with a pandemic potential.