Veterinary diagnosticians in Argentina have reported mortality due to HPAI in James’ flamingos (Phoenicoparrus jamesi). This “near threatened” species occurs on mountain lakes at high altitude in Argentina, Bolivia, Chile and Peru. To date 221 flamingos have been found dead in the Province of Catamarca as a result of H5N1 infection. Enigmatically, two other species of flamingo that cohabit with the James’ species have not been affected suggesting investigation of either epidemiologic or immunologic factors involved.